{"type":"standard","title":"7-Chlorokynurenic acid","displaytitle":"7-Chlorokynurenic acid","namespace":{"id":0,"text":""},"wikibase_item":"Q15634175","titles":{"canonical":"7-Chlorokynurenic_acid","normalized":"7-Chlorokynurenic acid","display":"7-Chlorokynurenic acid"},"pageid":41066963,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/2/2c/7-Chlorokynurenic_acid.svg/330px-7-Chlorokynurenic_acid.svg.png","width":320,"height":215},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/2/2c/7-Chlorokynurenic_acid.svg/520px-7-Chlorokynurenic_acid.svg.png","width":520,"height":350},"lang":"en","dir":"ltr","revision":"1244422399","tid":"4471e154-6cb4-11ef-804a-5339bc34e3b2","timestamp":"2024-09-07T00:58:17Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/7-Chlorokynurenic_acid","revisions":"https://en.wikipedia.org/wiki/7-Chlorokynurenic_acid?action=history","edit":"https://en.wikipedia.org/wiki/7-Chlorokynurenic_acid?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:7-Chlorokynurenic_acid"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/7-Chlorokynurenic_acid","revisions":"https://en.m.wikipedia.org/wiki/Special:History/7-Chlorokynurenic_acid","edit":"https://en.m.wikipedia.org/wiki/7-Chlorokynurenic_acid?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:7-Chlorokynurenic_acid"}},"extract":"7-Chlorokynurenic acid (7-CKA) is a tool compound that acts as a potent and selective competitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder, and anti-nociception. In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles, an action that it mediates via competitive blockade of vesicular glutamate transporters.","extract_html":"
7-Chlorokynurenic acid (7-CKA) is a tool compound that acts as a potent and selective competitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder, and anti-nociception. In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles, an action that it mediates via competitive blockade of vesicular glutamate transporters.
"}{"slip": { "id": 154, "advice": "State the problem in words as clearly as possible."}}
{"type":"standard","title":"The Little Old Lady (from Pasadena)","displaytitle":"The Little Old Lady (from Pasadena)","namespace":{"id":0,"text":""},"wikibase_item":"Q7747677","titles":{"canonical":"The_Little_Old_Lady_(from_Pasadena)","normalized":"The Little Old Lady (from Pasadena)","display":"The Little Old Lady (from Pasadena)"},"pageid":4495469,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/thumb/e/e3/Jan_and_Dean_Little_Old_Lady.jpg/320px-Jan_and_Dean_Little_Old_Lady.jpg","width":320,"height":306},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/e/e3/Jan_and_Dean_Little_Old_Lady.jpg","width":323,"height":309},"lang":"en","dir":"ltr","revision":"1287902455","tid":"b3a17afd-24b1-11f0-b8aa-13c5f828f35b","timestamp":"2025-04-29T04:23:29Z","description":"1964 single by Jan and Dean","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/The_Little_Old_Lady_(from_Pasadena)","revisions":"https://en.wikipedia.org/wiki/The_Little_Old_Lady_(from_Pasadena)?action=history","edit":"https://en.wikipedia.org/wiki/The_Little_Old_Lady_(from_Pasadena)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:The_Little_Old_Lady_(from_Pasadena)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/The_Little_Old_Lady_(from_Pasadena)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/The_Little_Old_Lady_(from_Pasadena)","edit":"https://en.m.wikipedia.org/wiki/The_Little_Old_Lady_(from_Pasadena)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:The_Little_Old_Lady_(from_Pasadena)"}},"extract":"\"The Little Old Lady (from Pasadena)\" is a song written by Don Altfeld, Jan Berry and Roger Christian, and recorded by 1960s American pop singers Jan and Dean.","extract_html":"
\"The Little Old Lady (from Pasadena)\" is a song written by Don Altfeld, Jan Berry and Roger Christian, and recorded by 1960s American pop singers Jan and Dean.
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